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UV application

Dermatological treatment

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Shenzhen Lamplic Technology Co., Ltd. has been used in the ultraviolet medical industry for more than 15 years. It has a large number of R&D teams. It has a very mature technical ability in the treatment of vitiligo and a breakthrough technology in the treatment of vitiligo. Ultraviolet Xtrac308 excimer laser treatment technology has a good effect in treating vitiligo. It is easy to use and is the gospel of vitiligo patients.
 
 
Phototherapy and photochemotherapy
 
 
(1) Phototherapy with narrow-band ultraviolet B (NB-UVB) has a certain effect in the treatment of localized or generalized vitiligo.
 
 
(2) Photochemical therapy (PUVA) is a good choice for localized vitiligo topical application of furan coumarins (8-MOP, psoralen tincture) and sunshine, which can be used in adults and children over 5 years old.
 
 
Specific medical certification excimer laser therapy
 
 
Principle of action:
 
 
Xtrac308 excimer laser therapy technology in the United States, its single 308 nm wavelength is considered to be the best wavelength for ultraviolet treatment of vitiligo. Studies have shown that excimer laser can increase the volume of skin melanocytes, prolong dendrites, increase the activity of tyrosinase, and enhance the ability of melanocytes to synthesize black. At the same time, the immunosuppressive effect on epidermis is also one of the mechanisms of treatment of vitiligo.
 
 
Xtrac excimer laser therapy system has passed strict verification with excellent clinical performance. In 2012, Xtrac excimer laser therapy system was the only laser treatment equipment approved by FDA of the United States and SFDA of China for vitiligo.
 
 
Xtrac excimer laser has three characteristics compared with traditional ultraviolet therapy: 1. The number of treatments needed and the cumulative dose of irradiation are more than that of conventional ultraviolet therapy, because it integrates 308 nm Xeel excimer laser source, 157 HZ quasi-continuous nanosecond modulation, precise dose control by computer and the latest liquid photoconductive transmission (LLG). Less; 2 patients with good compliance; 3 its beam is only a few centimeters, only to expose the affected skin to radiation, more safe and reliable.
 
 
Best-adapted population:
 
 
The curative effect of laser therapy varies with the location and age of onset.
 
 
Xtrac Excimer Laser Therapy System for the Best Suitable Population:
 
 
1. Facial neck and trunk are better than limbs. 2. Patients with vitiligo whose onset age is younger than 18 years old and whose constitution is weak have better curative effect.
 
 
3. Light beam does not harm pregnant women, so it is suitable for pregnant women.
 
 
4. Xtrac excimer laser treatment system is effective for advanced vitiligo.
 
 
In 2012, 308 nm excimer laser for dermatology clinical treatment is one of excimer lasers, xenon chloride (XeCl) excimer laser, which is a continuous pulse gas laser. Its wavelength is in the range of UVB, and its pulse width is generally about l0-30 ns. Clinical therapeutic laser emitters include Xtrac (PhotoMedex, USA) [4-6], Lambda Physics LPX105E [2, 3, 7, 8], and other types of emitters [9], often including XeCl gas system. Because XeCl dimer consists of inert gas xenon (8 electrons in the outermost layer) and halogen chlorine (7 electrons in the outermost layer), it is activated by current. Pulsed lasers are emitted in a combined state. The parameters of different laser emitters are slightly different. Taking Xtrac AL7000 as an example, the 308-nm laser pulse width is 30 ns, the repetition frequency is 157 Hz, the energy density of single pulse is 2-3 mJ/cm2, and the square spot of 2 cm*2 cm can be formed by using liquid photoconductive optical fiber to transmit the laser. During the treatment, the spot can be adjusted or the appropriate dose can be selected according to the need. In order to achieve the best therapeutic effect. All kinds of laser transmitters are easy to operate in clinic. The operator can transmit them hand-held. The handle can only move on the lesion and irradiate all lesions evenly. It can also be fixed in one part after irradiation for a period of time and moved to the adjacent part.
 
 
Up to now, the mechanism of 308 nm excimer laser is still not clear about the etiology and pathogenesis of vitiligo. There are many hypotheses to explain various clinical manifestations. The mechanism of 308 nm excimer laser in the treatment of vitiligo may be related to T cell apoptosis. Bian 2chi et al. showed that 308 nm excimer laser could remove infiltrated T lymphocyte in the lesion by immunohistochemical method. Novak et al found that 308 nm excimer laser could induce activated T cell apoptosis in vitiligo lesions. Its effect is more obvious than that of narrow-band ultraviolet radiation in inducing apoptosis. After irradiation, T cells apoptotic and the skin lesions not only disappear completely at the naked eye level, but also return to normal at the micro level. Vitiligo is characterized by selective melanocyte destruction and may be associated with autoimmune response. Narrow-band ultraviolet B (NB2UVB) may have immunomodulatory effects on cellular and humoral immunity, which can stabilize the depigmentation process. In addition, narrow-band ultraviolet (NUV) radiation has been widely recognized as similar to PUVA (psoralen photochemotherapy), which stimulates the accumulation of residual melanocytes in the outer root sheath of peripheral hair follicles. Melanocyte mitosis, melanin production and migration are often induced by various cytokines and inflammatory mediators, including interleukin-1, tumor necrosis factor-alpha, and leukotriene C4. Recent studies have shown that various cytokines and inflammatory mediators increase after UVB irradiation, suggesting that this is a mechanism of UVB-induced pigmentation recovery. Although no 308 nm excimer laser has been reported in this field, its wavelength belongs to the category of UVB, which suggests that it may also achieve therapeutic effect by increasing cytokines or inflammatory mediators.
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